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Chemistry

MAHRUKH AZAM

Contact Chemistry  

Chemistry

Address: 
750 South Church St. 
West Chester, PA 19383-2115


Phone: 610-436-2631 
Fax: 610-436-2890 
Email: Chem@wcupa.edu

MAHRUKH AZAM

MAHRUKH AZAM

  • B.S., Chemistry, Punjab University, Pakistan ; 1988
  • M.S., Chemistry, Quaid-e-Azam University, Islamabad, Pakistan; 1991
  • M.S., Biochemistry, Seton Hall University, South Orange, NJ; 1999
  • Ph.D., Biochemistry, Seton Hall University, South Orange, NJ; 2000

Courses taught:

  • CHE 476 Biochemistry I
  • CRL 476 Experimental Biochemistry I
  • CHE 477 Biochemistry II
  • CRL 371 Forensic Chemistry Laboratory
  • CHE 491 Seminar in Chemistry CHE 103 General Chemistry I
  • CRL 103 Experimental General Chemistry I
  • CHE 104 General Chemistry II
  • CRL 104 Experimental General Chemistry II
  • CHE 410 Independent Research

Research Blurb:

My research is about studying the four stranded G-rich quadruplex DNA, RNA and its interaction with small molecules using UV-Visible absorption, Fluorescence, and Circular Dichroism spectroscopy. The other area of interest is in yeast genetics and looking at mitochondrial proteins that are found to be synthetically lethal with mitochondrial acidic matrix protein, Mam33. One of these proteins, Mrpl4 is currently being studied in the lab for its role in mitochondrial function using S. Cerevisiae.

Research Interests:

  • Biochemistry
  • Research: Quadruplex DNA and RNA, Yeast genetics

Selected Reserach Publications

  1. Pag├ín, O.R., Rowlands, A. L.*, Azam, M., Urban, K.R.*, Bidja, A.H.*, Roy, D.M.*, Feeney, R.B.*, Afshari, L.K.* "Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones" Pharmacology Biochemistry Behavior, 2008, 89, 160-170
  2. Azam, M., Lee, J., Abraham, V., Chanoux, R., Schoenly, K., Johnson, F.B. "Evidence that the S. cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence" Nucleic Acids Research, 2006, 34, 506-516
  3. Anantha, N.V., Azam, M., Sheardy, R. "Porphyrin Binding to Quadruplexed T4G4" Biochemistry, 1998, 37, 2709-2714
  4. Rost, M., Zekunde, K., Azam, M., Starn, T., "Quantitative Measurement of "E-Juice" for Electronic Cigarettes" 5th Annual Pennsylvania Forensic Science Research Exchange, West Chester University, PA, April 2015
  5. Purohit, V., Yatssunk, L., Azam, M., "Small Molecule-DNA Interaction Using Different Spectroscopic Methods" Annual MidAtlantic Regional Meeting (MARM), Maryland, May 2011
  6. Azam, M., Frost, B., Knabb, M., Rieser-Danner, L., "Successful Implementation of Project-Based Biochemistry Laboratory Curriculum at West Chester University of PA" Annual MidAtlantic Regional Meeting (MARM), Maryland, May 2011
  7. Azam, M, "Biochemistry Laboratory Curriculum Revisions at West Chester University of PA" National 237th American Chemical Society Annual Meeting, Washington D.C. August 2009
  8. Butterworth, A.*, Chirayath, A. L.* Yatsunyk, L. , Azam, M. "Interaction of Cationic Porphyrin and its Metal Derivatives with Different G-Quadruplex DNA Structures" Second International Meeting on Quadruplex DNA, Louisville, KY. April 2009
  9. Azam, M., "Quadruplexes (Four Stranded DNA) at Telomeres and their Biochemical Role in Natural Aging Process and Cancer"Biology Department, Quaid-e-Azam University, Islamabad, Pakistan, (Invited talk) June 2008
  10. Butterworth, A.*, Chirayath, A. L.*, Azam, M. "Interaction of Copper Cationic Porphyrin with Quadruplex DNA Structures" First International Meeting on Quadruplex DNA, Louisville, KY, April 2007
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